- If you have a normally active social life, occasionally you may have indigestion. Indigestion irritates your stomach and makes your stomach ache. That's why it's very important for you to take Pepto-Bismol. Watch, Pepto-Bismol coats, soothes, protects, relieves the ache. Lets your irritated stomach return to normal. Now that protective coating is something your antacid probably can't do. Pepto-Bismol coats, soothes, protects.